Journal of Cancer & Metastasis Research

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Wnt inhibition may limit human salivary gland cancer progression

Author(s): Anita Joy*, Donald Reed, Aaron Altman, Kathryn Carter and Joshua Welborn

β-catenin is a multifunctional protein in the Wnt pathway, and acts as an intermediate for the association of the plasma membrane with the actin cytoskeleton, through binding E-cadherin and α-catenin. Its role as a linker protein between cells is crucial in maintaining E-cadherin’s adhesive properties. We aimed to evaluate β-catenin’s role in indirectly regulating cellcell adhesion and thereby influencing cell migration in an in vitro cell culture model


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