44 2033180199
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Managing Editor, Journal of Biomolecules and Biochemistry, United Kingdom


  • Opinion   
    Organogenesis depends on adhesion G-protein-coupled receptors (aGPCRs)
    Author(s): Marcel Bassil*

    Adhesion Organogenesis, neurodevelopment, reproduction, and other functions rely on G-protein-coupled receptors (aGPCRs) The Stachel sequence is a conserved internal (tethered) agonist sequence that activates several aGPCRs. GPR133 and GPR114, two aGPCRs in complex with Gs, were studied using cryogenic electron microscopy (cryo-EM). Both receptors' Stachel sequences adopt a helical-bulge sheet structure and insert into a binding site generated by the transmembrane domain, according to the structures (TMD). The majority of intramolecular interactions with the TMD are mediated by a hydrophobic interaction motif (HIM) within the Stachel sequence. Biochemical study of the HIM motif, when combined with cryo-EM structures, gives insight into the cross-reactivity and selectivity of the Stachel sequences... Read More»
    DOI: 10.37532/puljbb.22.6(2).20-21