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Acne Innovations

Acne is characterized by primary lesions on the face, chest, and back, and by a variety of other signs and symptoms. In particular, acne inflammatory lesions result from Propionibacterium acnes colonization and are of particular relevance as they will cause permanent scarring. In vitro studies have demonstrated that FAC is as effective as 5% peroxide in inhibiting growth of P. acnes. In 32 subjects with mild or moderate acne, FAC reduced all the main signs and symptoms of the disease. These included itching, erythema, and scaling, as well as reductions in the numbers of papules, pustules, and open and closed comedones. FAC was found to be effective in controlling sebum secretion, and was non-comedogenic. Most subjects (90%) reported tolerability nearly as good or excellent , while clinical efficacy and cosmetic acceptability were judged nearly as good . As acne is usually amid erythema, desquamation, burning, itching, dyschromia, and pain, the efficacy and tolerability of FAC, an acidic product, were investigated clinically.FAC was applied to the face, and to the left and right side of the suprascapular region of the back. Subjects were examined before the first-product application, and after 4 weeks of twice-daily treatment. Additional assessments included follicular biopsy and morphometric analysis of sebum and photographic evaluation.

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