Biosynthesis of silver nanoparticles as a platform for biomedicinal application

The biosynthesis of nanoparticles has been proposed as a cost effective and environmentally benevolent to chemical and physical methods. In the present study, one pot facile green synthesis of silver nanoparticles (AgNPs) has been demonstrated by using powder extract of dry ginger rhizome (Zingiber officinale). The structural analysis has been carried out by using Ultra Violet-visible spectroscopy, X-ray diffraction, scanning electron microscopy, energy dispersive X-ray analysis, transmission electron microscopy, atomic force microscopy, Fourier transform infrared spectroscopy and photoluminescence. The thermal stability has been also investigated by using thermo-gravimetric analysis. The biosynthesized nanoparticles investigated for their in-vitro antimicrobial activity in a dose-dependent manner against different pathogenic organisms under different temperatures and pH. It was noteworthy that AgNPs depicted promising antimicrobial activity. The reduction in the amount of reactive oxygen species (ROS) produced within the micro-organism cells treated with AgNPs and apoptosis have been investigated.