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Many anatomy textbooks describe the mandibular nerve. However, it’s branching and variations are many and inconsistent between individuals. Also the mandibular region that it supplies has its own variants. Our review article has taken into consideration articles describing these anomalous innervations by the mandibular nerve and its branches and their clinical relevance. The many variants have been documented after gathering information from all relevant review articles and case reports. This thorough review of branching and clinical correlation will be helpful for anesthetists, dentists and surgeons to get success of anesthesia, etiology of pathological processes and prevent surgical mishaps.