44 2033180199
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Applied Food Science Journal

Sign up for email alert when new content gets added: Sign up

Na Ren, Ping Liu*, Shuang Nie, Xuejiao Zhang and Mengdi Chen
 
Department of Hygiene Detection, College of Public Health, Shandong University, Jinan, Shandong, China, Email: [email protected]
 
*Correspondence: Ping Liu, Department of Hygiene Detection, College of Public Health, Shandong University, Jinan, Shandong, China, Tel: +86053188382554, Email: [email protected]

Received: 06-Mar-2019 Accepted Date: Mar 14, 2019; Published: 21-Mar-2019

Citation: Na Ren, Ping Liu, Shuang Nie, et al. Effects of trans-fatty acids on antioxidant system and ATPase levels in liver and kidney of rats. Appl Food Sci J. 2019;3(1):9-12.

This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http://creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes. For commercial reuse, contact [email protected]

Abstract

The study explored the effects of trans-fatty acids (TFA) on the antioxidant system and ATPase levels in liver and kidney of rats. Forty-eight healthy male Wistar rats of SPF grade were randomly divided into four groups according to their weight, which were control group, low dose TFA group, medium dose TFA group and high dose TFA group. The control group received 0.2 ml/kg corn oil once a day, while the TFA low dose group, TFA medium dose group and TFA high dose group respectively received 50, 100, 150 mg/kg/day trans-fatty acids, for 12 consecutive weeks. The tested chemicals were given by gavage. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), ATPase and the content of malondialdehyde (MDA) in the liver and kidney were determined. Compared with the control group, trans-fatty acids intake caused significant increase of MDA but reduction of the activities of SOD and GSH-Px (P<0.05) in liver and kidney, meanwhile, trans-fatty acids exposure caused a significant reduction of the activities of Na+ K+-ATPase, Mg2+-ATPase and Ca2+-ATPase (P<0.05) in liver and kidney. The results suggested that trans-fatty acid exposure can impair the antioxidant system and reduce the ATPase activity in liver and kidney of rats.

 
Google Scholar citation report
Citations : 11

Applied Food Science Journal received 11 citations as per Google Scholar report

Top